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Brent W. Winston, M.D., FRCPC, FACP, FCCP, FCCM

Associate Professor

Departments of Critical Care Medicine, Medicine, and Biochemistry and Molecular Biology. 
Member: Immunology Research Group and Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School Of Medicine, University of Calgary, Calgary, AB, Canada.

RESEARCH

Dr. Winston’s lab is conducting translational research involving critical care related illnesses. We are particularly interested in using NMR, GC-MS and LC-MS techniques to specifically examine:

1)  Metabolomics of sepsis.  We maintain and interest in examining metabolomics biomarkers and using metabolomics to examine
mechanisms of injury in pneumonia/sepsis and septic shock in ICU patients.
2)  Metabolomics of Acute Respiratory Distress Syndrome (ARDS). We are very interested in metabolomics fingerprint of ARDS (both from direct and indirect lung injury) and examining potential mechanisms involved in the mechanisms of ARDS development, severity of injury and the chronic lung changes secondary to ARDS.
3)  Metabolomics of traumatic brain injury (TBI).  We are interested in biomarkers that can be identified to help classify TBI (mild, moderate or severe), TBI prognostic biomarkers, and whether metabolomics can be used to identify mechanisms of injury in TBI.

Dr. Winston is also involved in a number of clinical trials involving sepsis, pneumonia, ARDS and TBI in the ICU. He is involved in a clinical trial of the potential of using mesenchymal stem cell (MSC) therapy for septic shock.

Recent Publications:

Lalu M.M. ; McIntyre, L.; Pugliese, C.; Fergusson, D.; Winston, B.W.; Marshall, J.C.; Granton, J.; Stewart D.J.; and the Canadian Critical Care Trials Group. Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): a systematic review of clinical trials. PLoS One. 2012;7(10):e47559.

Deirdre Church, Ingrid Slaba, Brent Winston and Robert Lindsay. Burn Wound Infections. In The Prokaryotes:The Prokaryotic Biology and Symbiotic Associations, 4th Edition. Eugene Rosenberg Editor. (Published 2013 on line: www.springerreference.com).

Beata Mickiewicz, Hans J Vogel, Hector R Wong, and Brent W. Winston. Metabolic profiling of serum samples by 1H NMR spectroscopy as a novel approach for early prognostic evaluation of pediatric septic shock and its mortality. Am. J. Respir. Crit. Care Med. rccm.201209-1726OCFirst published online March 7, 2013 as doi:10.1164/rccm.201209-1726OC

Beata Mickiewicz; Gavin E. Duggan; Brent W. Winston; Christopher Doig; Paul Kubes; Hans J. Vogel for the Alberta Sepsis Network (ASN). Metabolic profiling of serum samples by 1H NMR spectroscopy as a potential diagnostic approach for septic shock. Crit Care Med. First published online Dec 23, 2013. [Epub ahead of print]. Print version, CCM, 2014, 42(5):1140-1149.

Mohammad M. Banoei, Sarah J. Donnelly, Beata Mickiewicz, Aalim Weljie, Hans J. Vogel and Brent W. Winston. Metabolomics in critical care medicine, a new approach to biomarker discovery. Clinical and Investigative Medicine, 37(6), 2014, E363-376.

Graciela Andonegui, Peter M. Krein, Connie Mowat, Ron Brisebois, Christopher Doig, Francis Green, Caroline Léger and Brent W. Winston. Enhanced production of IGF-I in the lungs of fibroproliferative ARDS patients. Physiol Rep, 2(11), 2014, e12197, doi: 10.14814/phy2.12197.

Beata Mickiewicz, Patrick Tam, Craig N. Jenne, Caroline Leger, Josee Wong, Brent W. Winston, Christopher Doig, Paul Kubes and Hans J. Vogel for the Alberta Sepsis Network (ASN). Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit. Critical Care 2015, 19 :11 (15 January 2015). doi:10.1186/s13054-014-0729-0.

Mehdi Mirsaeidi, Mohammad Mehdi Banoei, Caleb K. Nienow, Taimur Abassi, Anoushirvan Hakim, Dean Schraufnagel, Brent W. Winston, Nadera Sweiss, Robert Baughman, Joe G.N. Garcia, Roberto Machado. Plasma metabolomics profile in fibrosing pulmonary sarcoidosis. Accepted for publication in Sarcoidosis, 2015.

Mehdi Mirsaeidi, Mehdi Mohammad Banoei, Brent W. Winston, Dean E. Schraufnagel. Metabolomics: Applications and Promise in Mycobacterial Disease. Ann Am Thorac Soc. 2015 Jul 21. [Epub ahead of print].

Beata Mickiewicz, Graham Thompson, Jaime Blackwood, Craig N Jenne, Brent W Winston, Hans J Vogel, and Ari R Joffe for the Alberta Sepsis Network. Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis. Crit Care. 2015 Sep 9;19:320. doi: 10.1186/s13054-015-1026-2.

A A Mourad, M M Banoei, S J Donnelly, and B W Winston. Predicting the mortality of pneumonia-induced direct lung injury using serum metabolomics. Extended abstract, Journal of Undergraduate Research in Alberta (JURA)¬, Vol. 5, 2015.

Yipp, BG, Winston, BW. Sepsis without SIRS is still sepsis. Ann Transl Med, 2015. doi: 10.3978/ j.issn.2305-5839.2015.11.13.

Mirsaeidi M, Banoei MM, Winston BW, Schraufnagel DE. Reply: Metabolomics and Mycobacterial Disease: Don't Forget the Bioinformatics. Ann Am Thorac Soc. 2016 Jan;13(1):142-3. doi: 10.1513/AnnalsATS.201510-711LE.

Manoj M. Lalu, Katrina Sullivan, Shirley  Mei, David Moher, Alex Strauss, Dean A. Fergusson, Duncan J. Stewart, Mazen Jazi, Malcolm MacLeod, Brent Winston, John Marshall, Brian Hutton, Keith Walley, Lauralyn McIntyreon behalf of the Canadian Critical Care Translational Biology Group. Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analysis prior to initiating a first-in-human trial. eLife, 2016:10.7554/eLife.17850.  November 15 ,2016.